Here are the details on main ingredients in curbing the menace of Advanced Glycosylation Endproducts.

Benfotiamine

Benfotiamine (S-benzyolthiamine-O-monophosphate) is a lipid soluble,
biologically active form of thiamin (vitamin B-1). It belongs to the
family of compounds known as allithiamines, which are found in crushed
garlic. Benfotiamine raises the levels of thiamin pyrophosphate (TPP)
which is the co-enzymated form of thiamin and also stimulates
transkotelase an enzyme responsible for maintenance of normal glucose
metabolic pathways. The activation of the enzyme transketolase, turns
triosephosphates which are glucose-derived compounds into chemicals
that are harmless. Thiamin activates it at level around 20%, which
isn’t enough to stop the glucose-derived compounds accumulating in
healthy cells where as Benfotiamine increases the levels of
transketolase by 300%! Benfotiamine prevents nerve and blood-vessel
damage caused by a build-up of sugar in the tissues. Benfotiamine
helps maintain integrity and health of cells in the presence of blood
glucose and controls formation of Advanced Glycation End products
(AGEs).

Vitacost’s NSI, Source Naturals carry Benfotiamine.

Pyridoxamine

Pyridoxamine is one of the three naturally occurring vitamin B6’s along
with pyridoxal and pyridoxine. Pyridoxamine is a potent natural
substance to inhibit glycosylation. In animal models, pyridoxamine has
inhibited development and progression of diabetic nephropathy and
kidney disorders for both Type 1 and Type 2 diabetes. Pyridoxamine is
also useful in addressing Advanced Lipoxidation Endproducts (ALE’s)
which is thought to be a precursor to atherosclerosis.

Jarrow Formulas produces Pyridoxamine product under the name Pyridoxall.

L-Carnosine

Carnosine is a combination of the amino acids beta-alanine and l-histidine. Carnosine is an important protector against bad side effects of the very things that life depends on such as oxygen, glucose, lipids, protein, trace metals. It protects the proteins of the body by acting as an antioxidant, anti-glycating, metal chelating agent. Carnosine’s structure is supposed to resemble glycation sites on proteins, there by accepting the damage and disposing off the damaging glycation end products.

Vitacost’s NSI, Jarrow Formulas, GNC, Source Naturals carry L-Carnosine.

Acetyl-L-Carnitine

Acetyl-L-Carnitine is the biologically active form of L-Carnitine and readily crosses blood brain barrier. Acetyl-L-Carnitine has been shown in animal models to suppress glycation and reduce advanced glycation end products.

Swanson, Jarrows Formulas, Vitacost’s NSI, Source Naturals, GNC, Vitaminshoppe carry Acetyl-L-Carnitine.

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The first and foremost important thing any diabetic, potential diabetic, insulin resistant or for that matter any person should consider is to stop the damage caused by Advanced Glycosylation Endproducts known as AGEs. Advanced Glycosylation Endproducts are formed when the proteins in our body are exposed to sugars particularly of sustained hyperglycemic phase. The damage of AGEs can be understood by looking at an example of how cooking food with sugar toughens them, similarly proteins in our body get inflexible by forming what are known as cross links.

Imagine how difficult it becomes for various organs to function properly if their protein fibers have become inflexible, roughened, damaged due to such cross linking of sugars and proteins. Advanced Glycosylation Endproducts are behind many degenerative disease processes suffered by diabetics and also of the general population such as  cardio vascular disease, kidney disease, cataracts, retinopathy, neuropathy, Alzheimer’s Dementia, impaired wound healing etc.

It’s of paramount importance to stop this process before it gets too far damaging various organ systems of the body. It’s often an overlooked aspect in conventional world and goes without any attention till the major damages start manifesting themselves in one disease or the other. But any sensible approach should address AGEs as the first step. When the house is on fire, one does not keep asking what, when, how kind of questions, but put the flames off first and save whatever, then think of the rest. It’s kind of similar situation with diabetes and damage due to Advanced Glycosylation Endproducts.

The following are supposed to play a key role in addressing Advanced Glycosylation Endproducts.

Benfotiamine

Pyridoxamine

L-Carnosine

Acetyl-L-Carnitine

We will examine what these are and how they can proactively limit the ravages of Advanced Glycosylation Endproducts in detail in the coming days…

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Here is a summary of nutrition for Adrenal Exhaustion, Burnout

Complete details may be found at mycfsrecovery.com

NADH

Acetyl-L-Carnitine

Coenzyme Q10 (CoQ10)

Pregnenolone

L-Tyrosine

Coenzymated B Complex

Pantethine

Vitamin B12 Sublingual Methylcobalamin

Magnesium Malate

Calcium Citrate Malate

Vitamin C

Omega-3s or Essential Fatty Acids

Chromium Polynicotinate

Opti Zinc

Vitamin A and Vitamin D

Melatonin

Digestive Enzymes

Probiotics

Sea Salt

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Without getting technical, it is simply an essential fatty acid that the body needs to function at optimal capacity and has broad range of benefits that can range a spectrum of disease processes. They improve cell membrane fluidity, protect the cells by forming part of the cell membrane and control inflammation. As our health is the aggregate of cellular health, we can see that these fatty acids indeed play an important role in our health.

Fish oil is the best source of omega-3s. Your second best bet is Flax seeds. But, two thirds of the population have difficulty converting flax oil to the actual omega-3s that the body needs. Also, it is important to consider the mercury, PCBs and other harmful pollutants in fish oil. Your best bet is wild salmon, as salmon body oils are low in these toxins. Also, it is important to select a product that is tested by independent bodies to be free of these toxins.

Carlson brand of Norwegian Salmon Oil comes close to meeting these exacting requirements of purity as it is routinely tested by independent bodies for impurities and find them to be of good quality.

Here is an article at University of Maryland Medical Center that gives good information on omega-3s which lists it to be useful for diseases like Cancer, Diabetes, Depression, Blood Pressure, Eating Disorders, Skin Disorders, Macular Degeneration etc.

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